As immunotherapeutic strategies move toward more complex engineering and multiplexed editing, there is a growing need to optimize the manufacturing of CAR-engineered cells for the clinic. Our laboratory is focused on bolstering the efficiency of CAR T cell enrichment, improving the precision of T cell editing using novel tools developed in the lab. Finally, we are expanding our technologies to other immune cells and are optimizing gene editing protocols and CAR designs for NK cells.
Improvement of Gene-Edited Immune Cell Manufacturing for Clinical Trials
We are collaborating with multiple labs at UCSF to establish a gene-edited immune cell clinical platform


Research Team

Alexis Talbot
Postdoctoral Scholar

Allison Rothrock
Research Associate

Chris Chang
MSTP Student

Joseph Muldoon
CRI Irvington Postdoctoral Fellow

Vincent Allain
Postdoctoral Scholar, UCSF / Graduate Student, University of Paris