Improvement of Gene-Edited Immune Cell Manufacturing for Clinical Trials

We are collaborating with multiple labs at UCSF to establish a gene-edited immune cell clinical platform
Improvement of Gene-Edited Immune Cell Manufacturing for Clinical Trials

As immunotherapeutic strategies move toward more complex engineering and multiplexed editing, there is a growing need to optimize the manufacturing of CAR-engineered cells for the clinic. Our laboratory is focused on bolstering the efficiency of CAR T cell enrichment, improving the precision of T cell editing using novel tools developed in the lab. Finally, we are expanding our technologies to other immune cells and are optimizing gene editing protocols and CAR designs for NK cells.

Selected Publications

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.
Nature 568, 112–116 (2019)
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Nature Medicine 25, 82–88 (2019)

Research Team

Alexis Talbot
Alexis Talbot

Postdoctoral Scholar

Allison Rothrock
Allison Rothrock

Research Associate

Chris Chang
Chris Chang

MSTP Student

Joseph Muldoon
Joseph Muldoon

CRI Irvington Postdoctoral Fellow

Vincent Allain
Vincent Allain

Postdoctoral Scholar, UCSF / Graduate Student, University of Paris

News

Media highlights of Eyquem Lab's research.
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors
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CRISPR-driven CARs
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CRISPR genome editing and immunotherapy – the early adopter
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CRISPR gene therapy is enhancing T-cell immunotherapy treatment of cancer and treatments in people could be available within 2 to 3 years
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Researchers Use CRISPR Gene-Editing Tool to Help Turn Immune Cells against Tumors
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Using CRISPR to Supercharge Cancer-Killing Immune Cells
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AACR 2018: An off-the-shelf, dual-targeted CAR T-cell product showed promising results in preclinical studies
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Curing Cancer with CRISPR
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Pancreatic cancer cells digest extracellular protein
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