High Throughput Tool Development for Accelerated CAR Engineering

We are using a gene editing and multiparametric single-cell analysis platform to accelerate the discovery of CARs with novel functions
High Throughput Tool Development for Accelerated CAR Engineering

Recent studies have determined that not all CARs are created equal in terms of effector function, persistence, and antigen sensitivity. Our laboratory has developed powerful T cell editing tools which allow for high throughput screening of CAR constructs, as well as discovery of new CAR architectures with augmented effector functions, persistence and sensitivity to antigen density.

Selected Publications

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.
Nature 568, 112–116 (2019)
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Nature Medicine 25, 82–88 (2019)

Research Team

Alexis Talbot
Alexis Talbot

Postdoctoral Scholar

Chang Liu
Chang Liu

Research Associate

Charlotte Wang
Charlotte Wang

Graduate Student

Chris Chang
Chris Chang

MSTP Student

Jing-Yi Chung
Jing-Yi Chung

Research Associate

News

Media highlights of Eyquem Lab's research.
HIT-T cell paper highlighted in Cancer Cell
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Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors
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CRISPR-driven CARs
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CRISPR genome editing and immunotherapy – the early adopter
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CRISPR gene therapy is enhancing T-cell immunotherapy treatment of cancer and treatments in people could be available within 2 to 3 years
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Researchers Use CRISPR Gene-Editing Tool to Help Turn Immune Cells against Tumors
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Using CRISPR to Supercharge Cancer-Killing Immune Cells
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AACR 2018: An off-the-shelf, dual-targeted CAR T-cell product showed promising results in preclinical studies
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Curing Cancer with CRISPR
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Pancreatic cancer cells digest extracellular protein
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