Recent studies have determined that not all CARs are created equal in terms of effector function, persistence, and antigen sensitivity. Our laboratory has developed powerful T cell editing tools which allow for high throughput screening of CAR constructs, as well as discovery of new CAR architectures with augmented effector functions, persistence and sensitivity to antigen density.
High Throughput Tool Development for Accelerated CAR Engineering
We are using a gene editing and multiparametric single-cell analysis platform to accelerate the discovery of CARs with novel functions
Selected Publications
Research Team
Alexis Talbot
Postdoctoral Scholar
Amrik Kang
MSTP Student
Chang Liu
Research Associate
Charlotte Wang
Graduate Student
Chris Chang
MSTP Student