Immunobiology of CAR T Cells in Solid Tumors

We are developing tumor models recapitulating a complex immunosuppressive microenvironment to understand the factors limiting CAR T cells in solid tumors.
Immunobiology of CAR T Cells in Solid Tumors

CAR T cells have shown poor therapeutic efficacy in solid tumors. To understand the challenges CAR T cells are facing in solid tumors we need mouse models that effectively recapitulate the complexities of the tumor microenvironment. Our lab is developing improved mouse models to investigate the interaction of CAR T cells with the different components of the solid tumor microenvironment and to identify mechanisms by which solid tumors induce dysfunction in CAR T cells.

Selected Publications

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28.
Frontiers in Immunology (2021)
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.
Nature 568, 112–116 (2019)
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Nature Medicine 25, 82–88 (2019)

Research Team

Angela To
Angela To

Research Associate

Chris Chang
Chris Chang

MSTP Student

Gabi Reeder
Gabi Reeder

Graduate Student

Jing-Yi Chung
Jing-Yi Chung

Research Associate

William Nyberg
William Nyberg

Postdoctoral Scholar

News

Media highlights of Eyquem Lab's research.
Response to Low Antigen Density Is Improved by HLA-Independent T-cell Receptors
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CRISPR-driven CARs
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CRISPR genome editing and immunotherapy – the early adopter
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CRISPR gene therapy is enhancing T-cell immunotherapy treatment of cancer and treatments in people could be available within 2 to 3 years
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Researchers Use CRISPR Gene-Editing Tool to Help Turn Immune Cells against Tumors
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Using CRISPR to Supercharge Cancer-Killing Immune Cells
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AACR 2018: An off-the-shelf, dual-targeted CAR T-cell product showed promising results in preclinical studies
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Curing Cancer with CRISPR
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Pancreatic cancer cells digest extracellular protein
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